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Li J et al

Traditional cigarettes Traditional cigarettes profoundly influence the oral microbiome (Fig

Related article: CYP2J2: Arachidonic Acid, Inflammation, and Heart Disease Related article: Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation CYP1A1 is also utilized in the metabolism of melatonin .[ref] Related article: Melatonin: Key to Health and Longevity New research points to a role in immune homeostasis in the intestines .[ref] Toll-like receptor 2 (TLR2) is part of the immune system that is active in the intestines and interacts with the gut microbiome

Further, as the immune system is longer capable of recognizing LDL it releases white blood cells and other substances to heal the damage caused and which eventually leads to inflammation and buildup of these harmful substances in the affected area