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These sex differences have declined since at least 1980, driven by smoking-attributable mortality, which tended to decline in males and increase in females overall

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The World Health Organization has also previously cited several health concerns associated with vaping, pointing out that: The long-term effects are unknown Nicotine in the liquid that is vapourised in an e-cigarette is addictive Users replacing the liquid in refillable e-cigarettes might spill the product on their skin, possibly leading to nicotine poisoning Some sweeter flavours of e-cigarettes are irritants, potentially causing inflammation of the airways

24 Over 20 experts on economics, epidemiology, public policy and tobacco control were asked by the International Agency for Research on Cancer (IARC) to evaluate the strength of the available evidence on the effects of tax and price policies to prevent and reduce tobacco use