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THC acts strongly on the pathway of the reward system in the brain

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P53 induces P21 expression [36, 37], which results in the formation of the RB-E2F complex that downregulates genes involved in the cell cycle, leading to cell cycle arrest and senescence [6, 36]

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Another easy substitute could have been plant-powered zero-nicotine puffs with selected aromas like watermelon, strawberry, peppermint to drive out stress and relax your brain