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Importantly, this study showed that in early tumourigenesis PM2.5 exposure in mice with pre-existing EGFR mutation promotes transcriptional reprogramming of AT2 cells to a state that is reminiscent of a progenitor cell [121]

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Cardiovascular Risk Marijuana use, mechanistically due to an increase in catecholamines, cardiac workload, and carboxyhemoglobin levels as well as episodes of significant postural hypotension, may trigger an increase in the risk of myocardial infarction, especially in older patients at risk for cardiovascular disease

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