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The ones affected indirectly are more mysterious, pointing out that we really dont know the mechanism by which smoking causes tumors in these tissues. Scientists did notice that tobacco increases risk of cancer in organs that are involved in metabolism and waste filtration, such as the liver, bladder, kidneys, and stomach

London: RCP (2007)

However, new generation non-combustible nicotine products can be an effective means of quitting smoking, especially when other interventions have proven unsuccessful

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A liquid-liquid extraction method using toluene and acidified water was developed, efficiently isolating pyrazines from nicotine, propylene glycol, and other flavor compounds