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NNMT is an enzyme that catalyzes the methylation of nicotinamide (a NAD+ precursor) and other substrates, using SAM (S-adenosylmethionine) as the methyl donor

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GCLC polymorphism has been shown to be associated with decreased GCLC expression in a patient with hemolytic anemia (Beutler et al., 1999), GSH levels and drug resistance among tumor cell lines (Walsh et al., 2001), decreased GCL activity and GSH levels in patients with schizophrenia (Gysin et al., 2007)