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When compared to the rest of the U.S., residents of Tobacco Nation states are less educated, not as financially well-off, and less likely to be employed, especially in white-collar jobs trends we noted in our first Tobacco Nation report that remain true today

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Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics

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