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Genomic analyses have demonstrated that smoking increases mutational burden, cellular heterogeneity, and frequency of driver mutations in human alveolar epithelial cells, increasing lung cancer risk [11]

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When to See a Doctor A person should consider seeing a healthcare professional if excess mucus: Does not improve after a reasonable amount of time Keeps coming back Interferes with sleep or daily activities Is associated with recurrent infections Includes blood Is accompanied by shortness of breath or chest tightness Note: Medical attention is especially important for infants, older adults, people with weakened immune systems, and individuals with existing lung disease