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Gangrene of the extremities, known as blackfoot disease, has been reported with drinking arsenic-contaminated well water in Taiwan, where the prevalence of the disease increased with increasing age and well water arsenic concentration (170800 parts per billion) [ATSDR 2007]

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With increase in ROS the spermatozoa is exposed to oxidative stress that causes the impairment in the sperm physiology that ultimately ends up in infertility