A few studies of persons with traumatic brain injury have found that alcohol use gets worse in the period 2 to 5 years after the injury and that unless something is preventing them, many resume their prior levels of alcohol and other drug use (Corrigan, Rust et al., 1995
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Nicotines main claim to fame, however, is how it hijacks our brains reward system to increase levels of the pleasure neurotransmitter dopamine, both stepping on the gas and cutting the brakes
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