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According to Dr Gigi Taguri, Director of Medical Technology here at LloydsPharmacy Online Doctor, there are 2 main reasons: 1

Compared with benchmark Lung cancer registrations (Persons All ages) Source: NHS England The rate of oral cancer registrations in Hull has been relatively variable but the rates appear to have increased between 2007-09 and 2015-17, and although there has been a fall between 2015-17 and 2017-19, but the latest rate in 2017-19 is considerably higher than the rate in 2007-09

Safety depends on the brand, ingredients, and whether the product complies with strict regulations such as those set by the UK or EU

[68] These toxins are of importance to medical research

And there is ample data about what they contain and what they do to a smokers health