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Changes in oxygen levels (hypoxia or hyperoxia) during development and fluctuations in blood flow and tissue perfusion can lead to oxidative stress (Torres-Cuevas et al., 2017)

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furthermore, test animals who were fed large amounts of acrylonitrile in their drinking water developed significantly lower body weight and other adverse effects, including lesions in the central nervous system and growths in the ear ducts. The FDA banned acrylonitrile beverage containers in March of 1977

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A single cigarette contains over 4,800 chemicals, 10 of which are known to cause cancer