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Differential expression of PGC-1 and metabolic sensors suggest age-dependent induction of mitochondrial biogenesis in Friedreich ataxia fibroblasts

Glucagon-like peptide-1 receptor agonists reverse nerve morphological abnormalities in diabetic peripheral neuropathy

Lancet (2017) 390:166475

doi: 10.1007/s10753-020-01338-2 10 TabasIRonD

Therapeutic strategies targeting mitochondrial dysfunction for comorbidity intervention (Table 2) Enhancing mitochondrial energy metabolism Mitochondrial protectants Coenzyme Q10, a well-established clinical therapeutic agent, is a component of the ETC and plays a dual role in facilitating electron transfer and exerting potent antioxidant effects