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A large proportion of participants exhibited hormonal imbalances, with one-fourth of participants having elevated FSH, one-third elevated LH, and 74.9% increased estradiol

When both receptor systems are activated, the cumulative impact on appetite and food thoughts might exceed what GLP-1 alone produces

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These compounds bind to NCOA4, disrupting its interaction with FTH1 and inhibiting NCOA4-dependent ferritin autophagy, thereby reducing intracellular free iron (Fe 2 ) levels and suppressing ferroptosis (Fang et al., 2021)