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The duration of semaglutide treatment plays a role in B12 requirements

Colder temperatures: Typical fridge temps range from 36F to 46F (2.2C to 7.7C), so you know that the insulin is kept at a consistently acceptable temperature before you open and start using a glass vial, insulin pen, or cartridge

While there are vitamin B12 foods available, some people have a harder time absorbing and actually utilizing this nutrient due to digestive or metabolic limitations

Researchers and clinicians using it do so based on extrapolation from animal data and accumulating clinical experience rather than proven efficacy in humans

Safety data is limited to the preclinical studies, where no adverse events were reported at therapeutic doses during the 11-week treatment period the longest published study duration