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Tgf-Beta1-Mediated repression of Slc7a11 drives vulnerability to Gpx4 inhibition in hepatocellular carcinoma cells

Liver injury caused by acetaminophen is initiated by cytochrome P450 (CYP)-mediated bioactivation to N -acety- para -benzoquinoneimine (NAPQI), which is a chemically reactive intermediate that is formed at high levels following overdosage and triggers a complex cascade of events, which ultimately result in hepatocellular necrosis (Hinson et al

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