For instance, exenatide, the first GLP-1-analogue developed, demonstrated to promote human monocyte differentiation into alternatively activated M2 macrophages, leading to an increase in anti-inflammatory cytokines such as IL-10 while significantly reducing pro-inflammatory cytokines, including IL-6, TNF- and IL-1 ( Furthermore, GLP-1 has been hypothesised to act as a mediator between innate and adaptive immune responses
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Feeling the benefits While semaglutides offer a much higher and longer lasting dose, which can provide quick, dramatic results, depending on what your usual diet is, Faiczak says you might see almost immediate benefits, with dietary changes alone
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