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Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial

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Sangokoya C, Telen MJ, Chi J-T

FOXO4-DRI has three main pharmacogenetic advantages: its stability (resistance to degradation by cellular proteases), half-life (compared to L-peptide equivalents, it's longer), and cell-penetrating properties (cell-penetrating sequences improve intracellular delivery)

However, results vary depending on individual health factors