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Although the aforementioned human studies provide important insights into the role of PYY in human metabolism, there are notable inconsistencies within the existing evidence, and these studies themselves have several key limitations that warrant cautious interpretation

It is widely studied in preclinical models for its pro-healing and tissue-protective properties

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Cortisol dysregulation driven by gut-derived immune signalling disrupts the normal circadian cortisol rhythm, impairing the deep sleep stages required for cellular repair