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The current evidence supports continued GLP-1 therapy for sustained weight management and metabolic benefits, with effectiveness maintained through combined pharmacological and lifestyle approaches rather than the medication losing its pharmacological action over time

Pharmaceutical GLP-1 receptor agonists work by directly binding to GLP-1 receptors throughout the body at sustained concentrations far beyond what natural production achieves

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Over time, natural hormone levels can decline, leading to reduced muscle mass, decreased energy, slower metabolism, and impaired recovery from physical activity