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A comparable concept to prediabetes remission has successfully been established in people with T2D in the DIRECT trial, where substantial weight loss led to a return to nondiabetic glucose levels in up to 85% of participants, although the risk of redeveloping T2D was high 15,16

Excess weight and insulin resistance can disrupt hormone balance, interfere with ovulation, and affect the uterine lining, making it harder to conceive, she says

Tirzepatide, marketed as Mounjaro and Zepbound, adds GIP receptor activation to GLP-1 effects

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