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EPA is more effective than DHA to improve depression-like behavior, glia cell dysfunction and hippcampal apoptosis signaling in a chronic stress-induced rat model of depression

In particular, neurons of the gastrointestinal system are highly sensitive to oxidative stress (219, 225, 226), which is a general hallmark of TD (227)

Ihubacter massiliensis: a new bacterium isolated from the human gut

In addition, LL-plSAM-FVpE had excellent M cell-targeting property to promote the phagocytosis and transport of the antigen SAM-FVpE by gastrointestinal M cells

An informative example worth considering is the HOPE-2 trial (49)