occasional irritation, flaking, or dryness have been reported at the start of use
Targeted central mechanism
Agents Linaclotide [5] Peptide agonist of guanylate cyclase-C Increases intestinal secretion of bicarbonate, chloride, and fluid, which improves fecal transit Lubiprostone [5] Prostaglandin derivative that activates chloride channels on the apical surfaces of enterocytes Increases intestinal fluid secretion and improves fecal transit Plecanatide [22] A guanylate cyclase-C agonist Increases intestinal secretion of bicarbonate, chloride, and fluid, which improves fecal transit Adverse effects Special patient groups Constipation in infants, children, and adolescents is detailed separately
Both patients were admitted to the intensive care unit (ICU) and received continuous dextrose infusions for 3 days
Over the past 10 years, the average water level sunk by 12 feet, according to a ground water levels report from the Colorado Division of Water Resources