Current evidence suggests that semaglutide does not pharmacologically suppress testosterone production through its GLP-1 receptor agonist activity
Even though more than 50% of patients experienced side effects, mainly gastrointestinal symptoms, it required stopping semaglutide use or dose mitigation in only ~16% of the patients, showing that this drug is well-tolerated, which is crucial for chronic weight management
In people with obesity or overweight and with type 2 diabetes, MariTide demonstrated up to an approximately 17 percent average weight loss at 52 weeks, also without evidence of a weight loss plateau, which Amgen said indicates scope for further weight loss beyond 52 weeks
The bottom line Yes, semaglutide does expire
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