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This indirectly suggests either a protective, or neutral, involvement of the oxidised forms of gliotoxin or sporidesmin in protecting against the deleterious effects of oxygen by selective protein inactivation

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Treatment with PLS was demonstrated to reduce oxidative stress, lower inflammatory scores, and decrease cox-2 expression, suggesting its promising potential in treating UC [151]

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Dosing was later increased to 5mg, each time with additional improvement and only transient mild nausea with the initial dosing