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The STEP 1 trial for semaglutide 2.4mg demonstrated a mean body weight reduction of approximately 14.9% over 68 weeks in adults with obesity. The SURMOUNT-1 trial for tirzepatide showed reductions of up to 22.5% at the highest dose. These are outcomes that approach the efficacy of bariatric surgery in some patient cohorts

Protective effects of melatonin on retinal inflammation and oxidative stress in experimental diabetic retinopathy

Patients should be offered this alternative after an informed discussion on the advantages and disadvantages of both treatment options

Maftouh, G.A

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