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Updated July 2026 Drug comparisons See all Retatrutide vs Tirzepatide (Zepbound): Triple Agonist vs Dual Agonist Retatrutide produces 28.7% weight loss (triple agonist) vs tirzepatide's 22.5% (dual agonist)

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NICE obesity guidance is clear about who qualifies and under what circumstances

The key difference is that semaglutide users at the 2.4 mg dose report higher rates and longer duration of constipation compared to tirzepatide users, even at the highest 15 mg dose

AFTER 2.5MG DOSE, THE DOSAGE PER INJECTION INCREASES GRADUALLY TO 5MG, THEN 7.5MG ETC TIRZEPATIDE 7.5MG IS THE RECOMMENDED MAINTENAINCE DOSE