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Studies were included if they reported outcomes related to remission or response rates, all-cause discontinuation, or changes in symptom severity using standardized behavioral scales

For heart failure or chronic kidney disease, the American Diabetes Association generally recommends SGLT2 inhibitors as first-line agents, with GLP-1 receptor agonists considered for their benefits on atherosclerotic cardiovascular disease, glycemic control, and weight management, or when SGLT2 inhibitors are not appropriate

But does it work and is it safe

Karl Nadolsky, endocrinologist and diplomate at the American Board of Obesity Medicine

Batule S, Ramos A, Prez-Montes de Oca A et al (2022) Comparison of glycemic variability and hypoglycemic events in hospitalized older adults treated with basal insulin plus vildagliptin and basal-bolus insulin regimen: a prospective randomized study