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Our focus is not merely on whether an effect is statistically significant, but rather on the magnitude of the effect size, the direction of cross-study fluctuations, and the underlying heterogeneityfactors that directly determine comparability and interpretative boundaries

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This lipid overload can induce insulin resistance, which further enhances renal urate reabsorption by activating the urate transporter 1 (URAT1) and sodium-dependent anion cotransporters in the proximal renal tubules

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