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The intraperitoneal administration of LPS, which is a cell wall component of gram-negative bacteria, such as Escherichia coli and Salmonella spp, increases intestinal permeability and causes the accumulation of phosphorylated -synuclein fibrils in the intestinal mucosa and dorsal vagal nuclei 27

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HFpEF is especially associated with age as well as female sex and conditions such as diabetes, obesity, hypertension, coronary heart disease and CKD

Patterns matter more than single days

This decision should be individualized based on your specific clinical context and treatment goals