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Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans

doi: 10.1093/ajcn/31.2.293

We will summarize these studies and discuss potential new formulations or adjunct therapies that might reduce skin sensitivity

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Restricting cysteine, depleting GSH, or inhibiting GPX4 can increase phospholipid peroxidation in responsive cells, but sensitivity also depends on lipid composition, iron metabolism, parallel antioxidant systems, and tissue context (Jiang et al., 2021)