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Carnitine thus plays a central role in the metabolism of fatty acids and energy by regulating the mitochondrial ratio of free coenzyme A to acyl-coenzyme A

Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice

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Diet-induced obesity is associated with an impaired NK cell function and an increased colon cancer incidence

Basic research supports this mechanism, demonstrating that fructose or HFD exposure induces mitochondrial structural abnormalities, mtDNA depletion, and ATP deficiency, ultimately impairing -oxidation and hepatocyte function