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the effects of testosterone on long-term bone metabolism are unclear, but are expected to have at least a protective effect on existing bone mass over time by preventing unwanted increases in bone turnover that are frequently associated with osteoporosis

Group III (10 patients) received oral placebo capsules (as a control) once daily for 4 weeks

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Incretin mimetics are particularly suitable for: Patients where weight loss would provide additional health benefits Individuals at high cardiovascular risk who may benefit from the cardioprotective effects of certain agents (liraglutide, semaglutide, dulaglutide) Patients wishing to avoid or delay insulin therapy Those requiring substantial HbA1c reductions to reach target levels NICE NG28 specifies continuation criteria for GLP-1 receptor agonists in triple therapy: continue only if there is a beneficial metabolic response, defined as a reduction of at least 11 mmol/mol (1.0%) in HbA1c and weight loss of at least 3% of initial body weight at six months