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When the stress response activates (whether from psychological stress, physical trauma, sleep deprivation, or environmental triggers), it directly stimulates mast cells to degranulate, releasing histamine and other inflammatory mediators into surrounding tissue and the bloodstream

Patients with heart failure or post-myocardial infarction patients given valsartan commonly have some reduction in blood pressure, but discontinuation of therapy because of continuing symptomatic hypotension usually is not necessary when dosing instructions are followed

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Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences