Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial
In the absence of sponsor-validated stability data, the following general principles apply to reconstituted injectable peptides in UK aseptic practice (as reflected in NHS Specialist Pharmacy Service guidance on aseptically prepared products): Reconstituted solutions prepared outside a licensed aseptic unit carry a higher risk of microbial contamination and chemical degradation Beyond-use dates must be assigned based on validated data, not on analogy with other products If no validated beyond-use date is available, the product should be used immediately or discarded It is important to note that antimicrobial preservatives in a diluent do not guarantee chemical stability of the peptide itself
Indicatively, mitochondrial dysfunction in neutrophils enhances the formation of neutrophil extracellular traps, contributing to tissue damage and autoimmunity in SLE
Acid labile linkers are a critical component in antibody-drug conjugates (ADCs) for achieving precise drug release
Turk MA, Hayworth JL, Nevskaya T, Pope JE
