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Sources This article was reviewed and approved by Alice Fletcher, Lead Bariatric Dietitian, on 1 September 2025

Hence, more investigations are needed to assess other signaling molecular pathways involved in MTX-induced intestinal injury to develop novel strategies for amelioration of intestinal injury induced by MTX

However, oxidative stress-mediated changes in cellular machinery allow Nrf2 to escape the degradation pathways and translocate to the nucleus

Effective pain relief through oxycodone demands not only pharmacologic expertise but also ethical responsibility, patient-centered communication, and vigilance against misusea collective endeavor that defines the essence of modern opioid stewardship