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According to NICE Technology Appraisal 875, Wegovy should be used within specialist weight management services alongside a reduced-calorie diet and increased physical activity, not as a standalone treatment

Inhibition of incretins by DPP-4 inhibitors prolongs the half-life of incretins (GLP-1 & GIP) and is associated with increased insulin release & reduced glucagon release

Reporting of harms associated with graded exercise therapy and cognitive behavioural therapy in myalgic encephalomyelitis/chronic fatigue syndrome

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