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Although experiments with transgenic mice have shown that in the absence of phase I oxidative pathways and therefore NAPQI formation, hepato-toxicity does not occur, the precise pathway lead-ing to liver damage is still unclear (Gibson et al ., 1996)

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Tranexamic Acid : Helps to reduce the appearance of dark spots and prevent new ones from forming by inhibiting the interaction between melanocytes and keratinocytes

Viewing SQOR as a metabolic rheostat reconciles these paradoxes and underscores therapeutic opportunities: metabolic supplementation (e.g., coenzyme Q10), selective inhibition or activation, and context-matched modulation

Heffernan M