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Neuroscience 82:12131223 Dringen R, Kranich O, Hamprecht B (1997) The -glutamyl transpeptidase inhibitor acivicin preserves glutathione released by astroglial cells in culture

The GSH-to-GSSG relationship is therefore dynamic

Hassler et al, 2018

Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents

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