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Findings of NAD and glutathione changes are reported in genetic metabolic diseases as well as in degenerative, age-related diseases 1,2

Among these proteins involved in biological processes, such as ECM organization, ECM disassembly, collagen metabolic processes, and cell substrate adhesion, five candidate proteins, including MMP2, MXRA5, ECM1, LGALS3BP, and LTBP4, caught our attention due to their potential to regulate fibrosis [11, 24,25,26,27]

Briefly, under anesthesia induced by intraperitoneal (i.p.) injection of ketamine (80 mg/kg) and xylazine (10 mg/kg), rats were exposed to octave-band noise (816 kHz) at 108 dB SPL for 2 h

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