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Two-year effects of semaglutide in adults with overweight or obesity (STEP 5)

Handling Lyophilised research peptide vials should be stored, logged, and handled using appropriate laboratory procedures and chain-of-custody records

Animal Model:High fat diet-induced obesity mouse model [3] Dosage:50 mg/kg Administration:i.p., twice per day for 28 days or 12 days Result:Did not alter brown adipose tissue mass, daily food intake and glucose metabolism, increased fatty acid oxidation (FAO) in normal in C57Bl/6 mice, but induced a progressive weight loss and decreased adipocytes size in high fat diet-induced obesity mouse models

Although not yet tested in PCa, this strategy could be particularly relevant for CRPC, given the elevated LPA levels in the tumor microenvironment and the redundant receptor expression that often limits the efficacy of single-receptor antagonists

New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio