doi: 10.1093/infdis/jis433 183 RaffatelluM.GeorgeM
Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible
doi: 10.1007/s00520-025-09315-x 12
98% is considered research-grade, but 99% purity is strongly preferred for collagen synthesis assays, gene expression studies, wound healing models, and skin biology research where compound purity directly affects experimental accuracy
We aim to offer both the principles underlying cellular dependence on glutamine metabolism under various conditions and a discussion of future directions that are leading our efforts to investigate the role of glutamine in cellular metabolism