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At the European Association for the Study of Diabetes conference in September 2024, researchers reported that in early trials, amycretin led to a 10.4% loss of body weight in people who were overweight or obese when taken at its lowest dose for 12 weeks

This is why Retatrutide is often discussed as a next-generation weight loss medication

In 2025, eight years after we pledged to embed patient perspectives into our decision making, we continued to strengthen access to medicines, enhance transparency in clinical research, and deepen collaboration with patient communities around the world

Skin sensitivity (unique to oral formulation) Some people taking the Wegovy pill report skin sensitivity, including burning feelings, tingling , or being more sensitive to touch

But how the weight comes off and what your body looks like and feels like at the end is shaped by whether you are moving