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Revised: Jul 2022 Side Effects for Janumet XR The following adverse reactions are also discussed elsewhere in the labeling: Lactic Acidosis [see WARNINGS AND PRECAUTIONS ] Pancreatitis [see WARNINGS AND PRECAUTIONS ] Heart Failure [see WARNINGS AND PRECAUTIONS ] Acute Renal Failure [see WARNINGS AND PRECAUTIONS ] Vitamin B12 Deficiency [see WARNINGS AND PRECAUTIONS ] Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues [see WARNINGS AND PRECAUTIONS ] Hypersensitivity Reactions [see WARNINGS AND PRECAUTIONS ] Severe and Disabling Arthralgia [see WARNINGS AND PRECAUTIONS ] Bullous Pemphigoid [see WARNINGS AND PRECAUTIONS ] Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Stoy N., Mackay G.M., Forrest C.M., Christofides J., Egerton M., Stone T.W., et al

The trial met its primary endpoint, demonstrating statistically significant and superior weight loss with CagriSema versus placebo

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Some individuals experience mild nausea, fatigue, or digestive changes during the initial adjustment period