The five classifications are: Class 1: enzyme deficiency with chronic nonspherocytic hemolytic anemia Class 2: severe enzyme deficiency, less than 10% of normal activity Class 3: moderate to mild enzyme deficiency, 10-60% of normal activity Class 4: very mild or no enzyme deficiency, at least 60% of normal activity Class 5: increased enzyme activity Pathogenic variants in the G6PD gene that result in non-spherocytic hemolytic anemia have all been found to cluster near the carboxy terminal end of the protein, whereas, the pathogenic variants that result in clinically mild symptoms are clustered near the amino terminal end of the protein
Biotransformed xenobiotics may also undergo autoxidation with concomitant ROS generation
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The dilutions of each primary antibody were 1:2000 for iNOS (Transduction Laboratories, Becton Dickinson Biosciences, Madrid, Spain) and 1:1000 for COX-2 (Cayman Chemical Company, Montigny le Bretonneux, France), and incubated overnight at 4C followed by peroxidase-conjugated anti-rabbit IgG antibody (1:3000) for 1 h
