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This paper is based on a presentation given at the Annual Meeting of the Society for the Study of Ingestive Behavior in July 2021 and provides a personal view on some of the milestones in the discovery of amylin as a constituent of pancreatic islet amyloid deposits, as a pancreatic beta-cell hormone, and on its role in physiology and pathophysiology

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The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

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Introduction Neurobehavioral and metabolic effects of GLP-1 RAs How GLP-1 RAs affect appetite Changes in cravings, mood, and behavior How GLP-1 drugs may reshape addiction pathways Clinical and public health implications Conclusions References Further reading The widely used obesity and diabetes GLP-1 drugs may do far more than reduce weight