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What the mechanism data actually says In human dermal papilla cell cultures, GHK-Cu has been shown to upregulate genes associated with anagen maintenance, including vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF)

Papp K, Reich K, Leonardi CL, Kircik L, Chimenti S, Langley RG, Hu C, Stevens RM, Day RM, Gordon KB, Korman NJ, Griffiths CE (2015) Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

However, due to sensitivity of Keap1 to ROS, this process is altered during OS, resulting in stabilization of Nrf2 and its nuclear translocation

Given the significant effect of time and our interest in the effects of the IF-P group, we prepared a GLM with age, sex, BMI, and time as covariates and corrected for FDR (Figure 5A)