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If clinically appropriate, they can continue at a higher dose aligned with recent treatment history

Compared with untreated controls, microsomal protein concentrations were increased after twenty-eight days of treatment in C57BL mice, after four and twenty-eight days of treatment in C3H mice, after four days of treatment in B6C3F1 mice, and with no effect of treatment in C3B6F1 mice

Cells were then washed twice with PBS containing 10% serum and fixed with 70% ethanol overnight at 20 C