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The canonical pyroptosis pathway is initiated by the activation of the NLRP3 inflammasome complex, which includes NLRP3, the adaptor protein ASC containing the CARD domain, and pro-caspase-1 [65]
It also benefits from clinical research and standardized treatment protocols , which make it a preferred option in regulated clinical environments
In recent research articles, new drugs such as GLP-1 (glucagon-like peptide-1 receptor agonists), SGLT2 (sodium-glucose cotransporter-2 inhibitors) and RAAS (renin-angiotensin-aldosterone system inhibitors) have been found to slow down the progression of DKD (110, 111)
(16) found higher degrees of exocrine pancreatic inflammation after treatment with exendin-4, with a significantly increased number of pyknotic nuclei, but just a trend toward more fibrosis
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