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Nature of action of sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals

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It activates the HGF/Met signaling pathwaypromoting synaptogenesis and dendritic spine formationat picomolar concentrations that exceed brain-derived neurotrophic factor and other nootropic compounds by several orders of magnitude

The Lavis group made a seminal discovery that substituting the dialkylamino group with an azetidine group is a general method to significantly improve quantum yields of fluorophores 17